electrical art and applied to the treatment of neurological disorders and neurological rehabilitation. We will investigate and develop micro- and milliwire techniques and applications to deliver neuromodulation, electrophysiological measurements (EP), and therapeutic stimulation.

Specifically, in Aim-1, we will develop a portable nanovoltammetry system for subcutaneous electrical neuro-stimulation, as a proof of concept. The proposed device will consist of a miniaturized micro-machined silicon probe, a nanovoltammetry system, an amplifier, an EMG system, and an electrode for electrochemical signal recording. In Aim-2, we will develop a compact, user-friendly, implantable micro-wire electrode for long-term in-vivo and long-term in-vitro stimulation at the microscale level. This electrode will be used for neuro-rehabilitation. Both Aims will lead to the development of new technologies for neurological rehabilitation.

Project Summary: Neurotherapeutics for stroke and traumatic brain injury, neuroimmunonotherapy and neurostimulation for epilepsy are key problems for the neurosciences. The goal is to develop, standardize and translate these emerging technologies to the clinic, in view of improved efficacy, safety, and convenience. The overarching goal of this project is to develop effective therapies for patients with acquired and genetic neurodegenerative and neuropsychiatric diseases using nanotechnology-based drug and/or gene delivery systems. In-particular, the central aim